Moving to NYU!

After seven and a half wonderful years at the Technion, I have decided to accept a position at NYU to direct the Institute for Computational Medicine. I formally start there in May and the Technion lab will close in August. I am very thankful to have had the opportunity to work at the amazing Faculty of Biology…

Developmental Milestones

Michal Levin, Tamar Hashimshony, Florian Wagner, and Itai Yanai. Developmental milestones punctuate gene expression in the Caenorhabditis embryo. Developmental Cell (May 2012) Developmental Cell paper Video Abstract Preview by Michael K Richardson: “A Phyloptypic Stage for All Animals?” Full Datasets: At GEO: GSE31422, GPL14142, GPL14143, GPL14144, GPL14145, and GPL14146 The complex process by which an animal develops from a single…

Evolution of the Germ Layers

Hashimshony T, Feder M, Levin M, Hall BK, Yanai I. Spatiotemporal transcriptomics reveals the evolutionary history of the endoderm germ layer. Nature. 2015 519:219-22. Editor’s summary: The germ-layer theory — which holds that all the cells and tissues of the body can be grouped into three fundamental layers — goes back to the roots of developmental biology…

The mid-developmental transition

  Levin M, Anavy L, Cole AG, Winter E, Mostov N, Khair S, Senderovich N, Kovalev E, Silver DH, Feder M, Fernandez-Valverde SL, Nakanishi N, Simmons D, Simakov O, Larsson T, Liu SY, Jerafi-Vider A, Yaniv K, Ryan JF, Martindale MQ, Rink JC, Arendt D, Degnan SM, Degnan BM, Hashimshony T, Yanai I. The mid-developmental transition and…

CEL-Seq2: Single-cell RNA-Seq

In 2012, our lab published CEL-Seq,  a method for single-cell RNA-Seq. The method is highly-multiplexed, uses in vitro transcription (IVT) to amplify, and has become one of the best methods for single-cell RNA-Seq. We believe it is actually THE best method! Here is the CEL-Seq protocol. This is how we freeze individual cells, though we also use a…

The Society of Genes

Here’s the website for the book: thesocietyofgenes.org Nearly four decades ago Richard Dawkins published The Selfish Gene, famously reducing humans to “survival machines” whose sole purpose was to preserve “the selfish molecules known as genes.” How these selfish genes work together to construct the organism, however, remained a mystery. Standing atop a wealth of new research, The…