scDual-Seq

Genome Biol. 2017 Oct 27;18(1):200. doi: 10.1186/s13059-017-1340-x. scDual-Seq: mapping the gene regulatory program of Salmonella infection by host and pathogen single-cell RNA-sequencing. Avital G1,2, Avraham R3,4, Fan A3, Hashimshony T2, Hung DT3,5,6, Yanai I7. The interaction between a pathogen and a host is a highly dynamic process in which both agents activate complex programs. Here, we introduce a single-cell RNA-sequencing method,…

Development and evolution through the lens of global gene regulation

Trends in Genetics has published this review on the Yanai lab’s contributions to evo-devo. Evolution and development are two inherently intertwined processes. As the embryo develops it does so in ways that both reflect past constraints and bias the future evolution of the species. While research exploiting this insight typically studies individual genes, transcriptomic analyses have sparked…