Zalts H and Yanai I. Developmental constraints shape the evolution of the nematode mid-developmental transition. Nature Ecology and Evolution 2017 doi:10.1038/s41559-017-0113 News & Views by Ronald E. Ellis Since the works of Ernst Haeckel and Karl Ernst von Baer in the 19th century, it has been recognized that a stage in mid-embryogenesis is remarkably conserved…
A Single-Cell Transcriptomic Map
Our pancreas transcriptomics paper just came out in Cell Systems! http://www.cell.com/cell-systems/fulltext/S2405-4712(16)30266-6 News and views about our paper: http://www.cell.com/cell-systems/abstract/S2405-4712(16)30328-3
Rob Knight Seminar
We are pleased to welcome Rob Knight for a seminar on Tuesday, September 13, 2016 for the inaugural lecture of microbiome seminar series. Rob Knight Professor, Departments of Pediatrics and Computer Science & Engineering University of California at San Diego “Spatial and temporal patterning of the human microbiome” 1:00pm – 2:00pm Refreshments at 12:30 Skirball…
NYU’s new Institute!
The Institute for Computational Medicine NYU School of Medicine’s Institute for Computational Medicine applies computational biology to medical challenges, tackling systems that are vast, complex, and dynamic. Our focus is on the fields of cancer biology, host-pathogen interactions, adaptive immune systems, and genetic diseases. We recognize opportunities in these disciplines require expertise in big-data analyses,…
Science book review
Joseph Swift has written a book review for ‘The Society of Genes’ in the March 25th issue of Science: “Despite the genome’s complexity, the authors are careful to keep the text accessible. Indeed, at times the reader may be reminded of those rare high-school teachers who could reveal the simple beauty hidden within abstract scientific theories.”…
Join the lab
We are excited to report that we have several openings in the Yanai Lab at the New York University’s School of Medicine. Our lab is currently situated in the West Alexandria tower (courtesy of the Institute of Systems Genetics), and we are scheduled to move into the 8th floor of the New Science Building in late…
Good Times!
A song for Gal Escape the Room! 2016 Foam Party! 2014 Lab photo 2013 Brainstorming Day 2014 Brainstorming Day 2013 Brainstorming Day 2012 Vlad’s bday 2012 Lab meeting Mustache party: Ronny’s Goodbye party Researcher’s Night at the Museum, 2009 Lab ‘worming’ party
Moving to NYU!
After seven and a half wonderful years at the Technion, I have decided to accept a position at NYU to direct the Institute for Computational Medicine. I formally start there in May and the Technion lab will close in August. I am very thankful to have had the opportunity to work at the amazing Faculty of Biology…
Developmental Milestones
Michal Levin, Tamar Hashimshony, Florian Wagner, and Itai Yanai. Developmental milestones punctuate gene expression in the Caenorhabditis embryo. Developmental Cell (May 2012) Developmental Cell paper Video Abstract Preview by Michael K Richardson: “A Phyloptypic Stage for All Animals?” Full Datasets: At GEO: GSE31422, GPL14142, GPL14143, GPL14144, GPL14145, and GPL14146 The complex process by which an animal develops from a single…
Evolution of the Germ Layers
Hashimshony T, Feder M, Levin M, Hall BK, Yanai I. Spatiotemporal transcriptomics reveals the evolutionary history of the endoderm germ layer. Nature. 2015 519:219-22. Editor’s summary: The germ-layer theory — which holds that all the cells and tissues of the body can be grouped into three fundamental layers — goes back to the roots of developmental biology…
The mid-developmental transition
Levin M, Anavy L, Cole AG, Winter E, Mostov N, Khair S, Senderovich N, Kovalev E, Silver DH, Feder M, Fernandez-Valverde SL, Nakanishi N, Simmons D, Simakov O, Larsson T, Liu SY, Jerafi-Vider A, Yaniv K, Ryan JF, Martindale MQ, Rink JC, Arendt D, Degnan SM, Degnan BM, Hashimshony T, Yanai I. The mid-developmental transition and…
CEL-Seq2: Single-cell RNA-Seq
In 2012, our lab published CEL-Seq, a method for single-cell RNA-Seq. The method is highly-multiplexed, uses in vitro transcription (IVT) to amplify, and has become one of the best methods for single-cell RNA-Seq. We believe it is actually THE best method! Here is the CEL-Seq protocol. This is how we freeze individual cells, though we also use a…
