BLIND

Several years ago, we presented the BLIND method which is able to determine the temporal order of transcriptomes in large datasets, thus allowing for the massive collection of samples, to be ordered at the analysis stage: Anavy L, Levin M, Khair S, Nakanishi N, Valverde SF, Degnan BM, and Yanai I. BLIND ordering of large-scale…

NYU’s new Institute!

The Institute for Computational Medicine NYU School of Medicine’s Institute for Computational Medicine applies computational biology to medical challenges, tackling systems that are vast, complex, and dynamic. Our focus is on the fields of cancer biology, host-pathogen interactions, adaptive immune systems, and genetic diseases. We recognize opportunities in these disciplines require expertise in big-data analyses,…

Science book review

Joseph Swift has written a book review for ‘The Society of Genes’ in the March 25th issue of Science: “Despite the genome’s complexity, the authors are careful to keep the text accessible. Indeed, at times the reader may be reminded of those rare high-school teachers who could reveal the simple beauty hidden within abstract scientific theories.”…

Join the lab

We are excited to report that we have several openings in the Yanai Lab at the New York University’s School of Medicine. Our lab is currently situated in the West Alexandria tower (courtesy of the Institute of Systems Genetics), and we are scheduled to move into the 8th floor of the New Science Building in late…

Good Times!

A song for Harel A song for Gal Escape the Room! 2016     Foam Party! 2014 Lab photo 2013 Brainstorming Day 2014 Brainstorming Day 2013 Brainstorming Day 2012 Vlad’s bday 2012 Lab meeting Mustache party: Ronny’s Goodbye party Researcher’s Night at the Museum, 2009 Lab ‘worming’ party    

Moving to NYU!

After seven and a half wonderful years at the Technion, I have decided to accept a position at NYU to direct the Institute for Computational Medicine. I formally start there in May and the Technion lab will close in August. I am very thankful to have had the opportunity to work at the amazing Faculty of Biology…

Evolution of the Germ Layers

Hashimshony T, Feder M, Levin M, Hall BK, Yanai I. Spatiotemporal transcriptomics reveals the evolutionary history of the endoderm germ layer. Nature. 2015 519:219-22. Editor’s summary: The germ-layer theory — which holds that all the cells and tissues of the body can be grouped into three fundamental layers — goes back to the roots of developmental biology…

The mid-developmental transition

  Levin M, Anavy L, Cole AG, Winter E, Mostov N, Khair S, Senderovich N, Kovalev E, Silver DH, Feder M, Fernandez-Valverde SL, Nakanishi N, Simmons D, Simakov O, Larsson T, Liu SY, Jerafi-Vider A, Yaniv K, Ryan JF, Martindale MQ, Rink JC, Arendt D, Degnan SM, Degnan BM, Hashimshony T, Yanai I. The mid-developmental transition and…

CEL-Seq2: Single-cell RNA-Seq

In 2012, our lab published CEL-Seq,  a method for single-cell RNA-Seq. The method is highly-multiplexed, uses in vitro transcription (IVT) to amplify, and has become one of the best methods for single-cell RNA-Seq. We believe it is actually THE best method! Here is the CEL-Seq protocol. This is how we freeze individual cells, though we also use a…

The Society of Genes

Here’s the website for the book: thesocietyofgenes.org Nearly four decades ago Richard Dawkins published The Selfish Gene, famously reducing humans to “survival machines” whose sole purpose was to preserve “the selfish molecules known as genes.” How these selfish genes work together to construct the organism, however, remained a mystery. Standing atop a wealth of new research, The…